High microalbumin, if it is caused by physiological reasons, usually does not appear the symptoms of generalized weakness; if it is caused by pathological reasons, it may cause generalized symptoms of fatigue. 1. Physiological reasons: such as strenuous exercise, high protein diet, pain stimulation, etc., may lead to elevated urinary microalbumin, which is generally a physiological phenomenon, and usually does not cause symptoms of generalized fatigue. 2. Pathological causes: such as chronic glomerulonephritis, urinary tract infections, acute and chronic renal failure, diabetic nephropathy, etc., microalbumin is a response to the early stage of renal disease, kidney injury indicators, due to the large amount of protein in the blood through the kidneys leakage into the urine, can appear weakness, poor nutrition, water electrolyte disorders symptoms. If you have high microalbumin, you may have early renal failure, and you need to go to the hospital in time to get a clear cause of the disease and then have targeted treatment to avoid delaying your condition.