Azoospermia is defined as the absence of sperm detected after 3 or more semen analysis tests and semen centrifugation. It is divided into obstructive azoospermia and non-obstructive azoospermia. 1. Non-obstructive azoospermia refers to problems with the spermatogenic function of the testes, and there is no problem with the ducts that discharge sperm. It is manifested by the presence of semen but no sperm. 2. Common types include 47,XXY (Creutzfeldt-Jakob syndrome), Y chromosome microdeletion (including AZFa deletion, AZFb deletion, AZFc deletion), testicular atrophy caused by secondary orchitis epididymitis, small testicular development (testicular volume less than 8ml), cryptorchidism or post-cryptorchidism, previous testicular biopsy diagnosed as only supporting cell syndrome, testicular sperm maturation block, testicular spermatogenesis Low testicular spermatogenesis, etc. 3. The therapeutic efficiency of mirror drugs for patients with non-obstructive azoospermia is about 7%. If the sperm produced effectively, because the number of sperm produced is small, usually tens, hundreds or thousands, because natural conception mostly requires tens of millions of sperm, so the vast majority can only produce their own offspring through IVF, expecting natural pregnancy to produce their own offspring, according to the current level of technology is not very realistic. 4. About 30-50% of people with non-obstructive azoospermia can have their offspring through IVF with the help of microscopic sperm retrieval techniques. The same sperm is usually obtained in dozens or hundreds, and can only be used to produce their own offspring through IVF, and cannot be conceived naturally.