In dermatology clinics, you can often see this scene: three generations of a family come together to see a doctor, and of course several adults are accompanying their grandchildren to see a doctor. Often the child is seen first, saying that the child is itchy, but when asked, the family of three generations all itch, and the itch is particularly pronounced at night. After examination, the doctor confirmed that the family all had scabies. Scabies is a contagious skin disease caused by infection with the scabies mite. Scabies is often caused by close contact with family members to infect each other, but also by contaminated bed sheets, clothing spread. After infection with the scabies mite, by sensitization, it causes intense itching, and the itching is intense at night, or intensifies after washing hot water. It is still tolerable during the day, but persists. Therefore, when more than one person in the family has symptoms of itching, the possibility of infection with scabies should be considered. The scabies mite is a parasite that infects human skin, and the female burrows into the cuticle of the skin to lay eggs, and itchy papular damage and epidermal peeling and tunneling occur. The lesions occur in areas of thin skin, such as between the fingers, wrists, armpits, areola, umbilicus, lower abdomen, genitals, and buttocks. In adults, the head and face are often uninvolved, while in infants the lesions are widespread. Sometimes the rash may also be atypical and appear as eczema-like changes or pustules due to factors such as infection and scratching. Scabies nodules are valuable for the diagnosis of scabies. Scabies nodules appear as dark red nodules, about 3 to 5 mm in diameter, which may be pruritic and usually persist in the scrotum, penis, and female genital area. The definitive diagnosis of scabies relies on the detection of scabies mites under a microscope. The lesions are usually scraped on the fingers, wrists, or in the armpit or genital area and examined under the microscope. For the treatment of scabies, lindane ointment, which is composed of benzene hexachloride, is currently used domestically. The application of Lindane ointment is that the drug should be applied thoroughly from the neck to the feet, especially to the folds, the perianal area, the umbilicus, and the free edge of the nail, and washed off after 8 to 10 hours. Also clothes, quilts and bed sheets should all be ironed. Use sulfur ointment mainly for pregnant women and young children under 2 years old. Apply the same area as Lindane ointment, but use it for 3 consecutive days. Those who are in close contact with the patient need to be treated at the same time, which means that the family should be treated with medication together, even without any itching or clinical symptoms home. If one person does not get well, there is a risk of reinfestation. To reduce re-infestation by contaminant vectors, clothing, fabrics and towels used during each treatment need to be washed in hot water or dried at high temperature or kept in a bag for 10 days. Also quilts, sheets, etc. should all be ironed and washed. Itching and lesions can persist for 2 to 4 weeks after successful treatment. This is often referred to as an itchy extension of scabies. This reaction does not indicate a failure of treatment, but rather indicates that the body is reacting to the dead scabies mite. within 2 weeks it will disappear with the natural peeling of the epidermis. However, more often than not, the itch disappears within 3 days. To reduce re-infestation by contaminating agents and to ensure killing of the worm, a second topical application can be made after 1 week. Scabies nodules can be treated with topical glucocorticoid ointment or intra-dermal glucocorticoid injections.