Injuries from iron nails can lead to tetanus infection if tetanus antitoxin is not administered. Tetanus is a specific infection often associated with trauma, and the tetanus bacillus most often hides in the soil, with large numbers of tetanus bacilli often present in rust. Moreover, tetanus requires a hypoxic environment for its development, so if the wound is deep and the external opening is small after being stabbed by an iron nail, it is easy to be infected with the possibility of tetanus. Therefore, the first thing to do after being stabbed by a nail is to treat the wound, and wash the wound with running water; if necrotic tissue remains in the wound and the drainage is not smooth, it is also necessary to debride the wound after anesthesia and drain the wound. Thereafter, early application of tetanus antitoxin to neutralize the free toxin and penicillin to prevent and control infection are essential.