Hyperuricemia is a metabolic disorder caused by abnormal purine metabolism. The end product of purine metabolism is uric acid, and if too little is excreted or too much is produced, this can lead to an increase in the concentration of uric acid in the body’s serum. The causes of high uric acid are exogenous uric acid and endogenous uric acid. primary hyperuricemia has the following causes: 1. excessive uric acid production, excessive intake of high purine foods, defects in enzymes in the process of purine metabolism can lead to excessive uric acid production. 2. decreased uric acid excretion, diseases that cause abnormal kidney function, resulting in decreased uric acid excretion. Secondary causes of hyperuricemia: 1) hyper catabolism of proteins in the body, such as hematological diseases, chemotherapy, radiotherapy, etc. 2) decreased uric acid excretion, renal insufficiency due to various renal diseases and certain drugs (such as thiazides, furosemide, ethambutol, etc.). Hyperuricemia is an independent risk factor for metabolic diseases (diabetes, metabolic syndrome, dyslipidemia), chronic kidney disease, cardiovascular disease, stroke and other diseases. Hyperuricemia and gout are inextricably linked and are the biochemical basis and most direct cause of gout. The harm caused by gout to a person can be joint deformity and dysfunction, gout stones, leading to renal colic, kidney damage, such as renal insufficiency, kidney failure, and increased death from coronary heart disease. In short, gout is more harmful to people, but the main reason is due to high uric acid, so for high uric acid must be actively treated.