Fat necrosis of the breast mostly occurs in lipid-rich, hypertrophic, drooping type of breast, often with a history of local trauma. Symptoms The onset of the disease is often rapid, with sudden onset of hard, lumpy breasts that are adherent to the skin and may be painful to distinguish from breast cancer. However, the axillary lymph nodes are often not enlarged. The lymph nodes in the armpit are not enlarged and rarely continue to increase in size. The lump is shadowed with unclear border, burr-like, and microscopic calcified spots are visible, etc. II. Treatment Excisional biopsy is the treatment of choice.