Tonicare is estradiol valerate tablets, which usually cause menstruation 3 to 7 days after stopping the medication. Estradiol valerate tablets are mainly used for the treatment of postmenopausal menopausal symptoms or sweating, sleep disorders, mood depression caused by estrogen deficiency. Generally in the process of use may cause breast swelling and pain, stomach upset and other adverse reactions. Therefore, it is forbidden to use it for people who are allergic to the ingredients of the drug, people with abnormal liver function or people with thrombotic diseases. Pre-adolescent children and pregnant women are prohibited from using it. The mechanism of action of estradiol valerate tablets is basically similar to that of estrogen, which will lead to the thickening of the endometrium. Therefore, the thickened uterine lining will gradually fall off and normal menstruation will occur in about 3-7 days after stopping the medication. Women should use hormonal drugs or endocrine regulators with caution under the guidance of a doctor.