Taking isosorbide nitrate after a heart attack may cause pain in the temples. After the occurrence of heart attack patients need long-term oral drug therapy, the basic drugs include aspirin, atorvastatin and other drugs, such as patients after myocardial infarction still have angina approach, need to take oral isosorbide nitrate for treatment. Isosorbide nitrate has the role of dilating coronary arteries, can increase the blood supply of coronary arteries to improve the symptoms of angina pectoris, and at the same time on the cerebral vasculature also has the role of dilation, expansion of cerebral blood vessels, the patient can appear headache symptoms, such as part of the patient can be manifested as pain in the temples. Isosorbide nitrate is mainly used in the treatment of coronary heart disease, the adverse effects of the drug are headache, nausea, vomiting, tachycardia, etc. It is forbidden for patients who are allergic to the components of the drug, glaucoma, and increased intracranial pressure. When taking isosorbide nitrate orally, pay attention to the adverse reactions of the drug, such as the emergence of uncomfortable symptoms, should go to the hospital in a timely manner, under the guidance of the physician for treatment.