Kawasaki disease 4 days after the infusion of gammaglobulin again fever, considered as gammaglobulin-resistant Kawasaki disease, can be prescribed a second gammaglobulin shock or hormone therapy. Kawasaki disease is a systemic vasculitis of unknown etiology, the clinical manifestations are mainly recurrent persistent high fever, with red eyes, red lips, hard swelling of the ends of the fingers and toes, enlarged lymph nodes, polymorphic rash and other manifestations, the vast majority of patients with a gammaglobulin can be used once the body temperature can be reduced to normal, a small number of patients will be back to the fever. Kawasaki disease often leads to coronary artery involvement, so it is necessary to dynamically follow up cardiac ultrasound, electrocardiogram, closely monitor the coronary artery condition, and under the guidance of the doctor oral aspirin anti-platelet aggregation to prevent myocardial infarction.