Thyroglobulin antibody of 4000IU/ml is on the high side, if it is simply elevated, asymptomatic, and the thyroid function is normal, no special treatment is needed; if it is caused by Hashimoto’s thyroiditis, Graves’ disease and other diseases, treatment is usually needed. Thyroglobulin antibody is a common autoantibody in the serum of patients with autoimmune thyroid disease, and the normal value should be less than 60IU/ml (the reference range may vary according to different testing instruments in each hospital, please refer to the reference range on the laboratory report), which is clinically valuable for the regression and treatment of thyroiditis, especially Hashimoto’s thyroiditis. If it is simply elevated and the thyroid function is normal, there is no clinical manifestation, and the thyroid ultrasound is normal, usually no treatment is needed, and regular checkups are sufficient. However, if the elevation is caused by Hashimoto’s thyroiditis, Graves’ disease, or other diseases, targeted treatment is required under the guidance of a doctor. If thyroglobulin antibodies of 4000IU/ml are present, it is recommended to go to the hospital and ask the doctor to determine whether treatment is necessary.