There is no better use of lipoic acid or epalrestat, and it is recommended that you choose the most suitable medication for your condition under the guidance of your doctor. Lipoic acid is mainly indicated for the treatment of diabetic polypoidal peripheral neuropathy, and patients may experience adverse reactions such as swelling of the head, breathing difficulties, hives or eczema after use. It is contraindicated for those who are allergic to the drug. Epalrestat is mainly used for the treatment of diabetic neuropathy, patients may have adverse reactions such as erythema, blisters, diarrhea, nausea, loss of appetite, and elevated bilirubin after use, and is contraindicated in those who are allergic to Epalrestat. Both drugs have a certain effect on diabetic neuropathy, but different patients take the drug efficacy is different, so the two are not comparative significance, patients need to choose under the guidance of the doctor suitable for their own drugs to take. If the effect after using the drug is not satisfactory, we should communicate with the doctor in time to see if we need to change the drug to ensure the effectiveness of the treatment.