Amoxicillin should not be applied topically to wounds. Amoxicillin is one of the more widely used oral semi-synthetic penicillin, the preparation includes capsules, tablets, granules, dispersible tablets, etc., clinically not for topical external use. Amoxicillin is mainly metabolized by the liver into the peripheral circulation to exert its efficacy after oral administration, and if used for local topical wounds may lead to skin tissue damage, or even allergic reactions. In addition, during the administration of the drug, some patients may experience nausea, vomiting, diarrhea, rash, asthma, anemia, thrombocytopenia, eosinophilia, mild increase in serum aminotransferase and other adverse reactions, and a very small number of patients may experience central nervous system symptoms such as euphoria, anxiety, insomnia, dizziness and behavioral abnormalities. It is recommended to standardize the use of the drug under the guidance of a professional doctor, do not use the drug without authorization.