Children with fever-reducing drugs do not reduce fever can be seen in more serious conditions or in the acute stage of the disease, the use of antipyretic drugs dose is insufficient and insufficient observation time after the use of drugs and other situations. 1. Serious illness: in some serious diseases, such as intracranial infection, sepsis and other conditions, there can be repeated fever, part of the temperature can be super-high fever, such as body temperature of more than 41 ℃, the above situation can appear although the correct use of antipyretic drugs, but the temperature does not drop the ideal situation. The extreme stage of the disease, such as influenza, may also appear to be unable to reduce the fever, but with the changes in the course of the disease and timely treatment, the body temperature can gradually tend to normal. 2. Insufficient dosage of antipyretic drugs: When the body temperature rises, the appropriate dosage of drugs is not given according to the body weight, and if the dosage is insufficient, the effect of antipyretic drugs may be unsatisfactory. It is necessary to give antipyretic drugs under the guidance of a physician. 3. Insufficient observation time after the use of drugs: usually after the correct use of drugs, the body temperature gradually decreases in about 30 to 60 minutes, and some patients’ temperature gradually decreases in 1 to 2 hours, which needs to be judged by specialists according to the children’s conditions if necessary. It is recommended that children whose fever does not go down with antipyretic medication should seek prompt medical attention from a specialist to complete the examination, make a clear diagnosis and take corresponding therapeutic measures.