Active SLE usually tends to go into remission after hormone and other treatments and turns into stabilizer (remission phase). Since there is no root solution so far, the disease turns from the stabilizer phase to the active phase under the influence of certain triggers, such as infection, pregnancy, surgery, exertion, and drug withdrawal. Clinically, a patient in remission should be considered to have a relapse of the disease if the following symptoms and abnormalities in the examination occur. 1. Fever of unknown origin. That is, the fever cannot be explained by a cold, pharyngeal, pulmonary, or urinary tract infection, and is not due to other diseases; 2. Fresh rash reappears or is accompanied by a vascular-like rash on the ends of the fingers (toes) or other parts of the body; 3. Swollen and painful joints reappear; 4. Significant hair loss; 5. Fresh ulcers of the mouth and nose; 6. The appearance of pleural or pericardial effusion 7. Increased proteinuria; 8. Significant leukopenia or thrombocytopenia or anemia; 9. Presence of neurological symptoms, such as headache, vomiting, and convulsions; 10. Increased titer of anti-double-stranded DNA antibody; 11. Increased blood sedimentation, as 50 ml/hour or more FFB12. Decreased complement, especially C3. Combined with the medical history and detailed physical examination, it is generally not difficult to make a judgment of disease recurrence. Complement C3 and anti-double-stranded DNA antibodies are often laboratory indicators of SLE activity. Therefore, in order to detect changes in the disease in a timely manner, patients with fever should go to the hospital for examination in a timely manner. Doctors require patients to have regular blood tests for the purpose of early detection of changes in the disease. There are clear reasons for relapse, such as sudden discontinuation or rapid reduction of hormones, or excessive fatigue. One farmer patient had a relapse of lupus disease every summer or after the autumn harvest, due to strong sunlight exposure. There are also relapses during pregnancy or after childbirth. There are also relapses for reasons that are not clear. It should be noted that other diseases must be ruled out for the relapse of the disease, and one should never simply consider a positive antinuclear antibody or a non-decreasing antinuclear antibody titer as a relapse, because antinuclear antibodies do not necessarily parallel the disease activity. Nor should headaches and vomiting be simply considered as a relapse, exacerbation of lupus or a combination of encephalopathy. A patient who had been ill for many years adjusted her hormones on her own without following medical advice and added a few hormones whenever she had some discomfort. After taking hormones and immunosuppressants for a long time for several years, her immune function declined and she became infected and was confirmed to have cryptococcal meningitis by lumbar puncture of cerebrospinal fluid and was hospitalized for up to 8 months.