Hepatitis B virus 4 times square is generally not serious, but it is more serious if there is abnormal liver function or cirrhosis. Hepatitis B virus 4 times square indicates that there is replication of the hepatitis B virus in the body, but the viral load is at a moderate level, and the virus replication is not particularly active. Most people are not serious, and it is necessary to combine the presence or absence of liver injury and other pathologies such as cirrhosis to determine whether there is cirrhosis or not. If Hepatitis B virus 4 times combined with elevated aminotransferases and elevated bilirubin, this group of patients is relatively serious and requires aggressive antiviral treatment. Hepatitis B virus 4 times combined with cirrhosis, or even combined with liver cancer, these patients are also more serious, usually need long-term antiviral treatment, and should pay attention to some complications of hepatitis B, such as spontaneous peritonitis, hepatic encephalopathy, hypoproteinemia and so on. It is recommended to consult a doctor in time when you find positive hepatitis B virus.