Timosartan has a certain effect on reducing urinary protein, it is an angiotensin receptor antagonist, clinically mainly used in the treatment of hypertension, Timosartan can also reduce proteinuria, reduce intraglomerular pressure, thus playing a role in protecting the kidneys. At present, the mechanism of angiotensin receptor antagonist to reduce proteinuria is not clear, the possible mechanisms include reducing renal vascular resistance, reducing glomerular transmembrane pressure, thus reducing protein filtration; adjusting the synthesis of heparan sulfate, the main component of the glomerular basement membrane, and reducing its permeability to macromolecules thus reducing proteinuria. For patients with mild renal insufficiency combined with proteinuria and hypertension, angiotensin receptor antagonist drugs, such as timosartan, can be the first choice. It should be noted that in the case of low blood volume or severe renal insufficiency, such as creatinine clearance less than 30ml/min or blood creatinine concentration more than 265μmol/L, the application of angiotensin receptor antagonists may continue to deteriorate renal function, so when using the drug, the patient’s creatinine clearance and blood creatinine changes should be monitored, and the drug should be discontinued promptly in the event of abnormalities. It is recommended that patients with urinary protein go to the hospital in time for treatment under the guidance of the doctor.