Aspirin and ibuprofen can be taken together, both of which are actually antipyretic and analgesic drugs. In terms of antipyretic and analgesic, aspirin has a weaker effect and ibuprofen has a stronger effect, but aspirin also has an anti-platelet aggregation effect, so it is most widely used in clinical practice not for antipyretic and analgesic but for preventing cerebral infarction. Many patients with cerebral infarction often have migraine, a kind of vascular headache, which is treated in the acute stage by oral antipyretic and analgesic drugs such as ibuprofen or naproxen. So, if a patient is already taking aspirin and still has a headache, he or she can also take ibuprofen. Although aspirin can be used for a long time, ibuprofen should not be used for a long time. The side effects of this drug are relatively large and can cause increased secretion of stomach acid, which can easily lead to damage of the gastric mucosa. When it is combined with aspirin, the adverse effects on the gastric mucosa can be even stronger and may lead to erosion and bleeding of the gastric mucosa, so be careful to take it after meals and use it only for a short time and temporarily.