Cranial defects are usually caused by craniocerebral trauma, brain surgery to remove bone flaps, tumor removal, chronic osteomyelitis of the skull, etc. After cranial defects, cranial defects, the brain tissue loses its strong protection and is exposed to atmospheric pressure, which directly affects the normal functioning of the tissues in the brain; they also cause the patients to have a strong sense of inferiority due to their unattractive appearance, resulting in the decline of the quality of the treatment of life. With people’s awareness of health and the demand for appearance, many patients actively seek surgery to repair cranial defects and regain their health. With the development of modern medical technology, cranial repair has gradually become a routine neurosurgery, and the concept of repair, pre-operative program design, post-operative procedures, and post-operative care measures have been developed very well, so patients can rest assured that the repair. Cranioplasty opens up a new life for patients with cranial defects. The surgery not only allows patients to restore the integrity of the skull in a short period of time, but also allows them to have a high quality of life. It can also satisfy the patients’ needs for aesthetic enhancement and improve their self-confidence. Therefore, timely repair by patients is of great significance to their physical health, overall image, and psychological aspects. What are the best materials currently available for cranial bone repair surgery? In the field of modern medicine, cranial bone repair materials can be said to be endless, each period has its representative materials, but due to various defects, disappeared with the progress of history. Currently, the representative materials are titanium mesh and peek, which cannot become particularly suitable because of the drawbacks of titanium mesh such as rejection of infection, cutting of skin, and exposure of titanium mesh from time to time. In recent years, a new type of polyether ether ketone PEEK material is becoming a new trend in cranial bone repair materials, its performance is very excellent, to carry out polyether ether ketone peek cranial bone repair and plastic surgery, the rate of postoperative rejection of infection is low, high comfort, beautiful appearance, by the many patients with cranial bone defects unanimously praised.