The difference between brain lymphoma and glioma lies in the pathogenesis, clinical symptoms, scope of invasion and treatment modalities of both. 1. Pathogenesis: The pathogenesis of brain lymphoma is often related to EBV, human T-cell lymphotropic virus type I, etc. Secondly, low immunity function of human body is also related to the pathogenesis of brain lymphoma. The pathogenesis of brain glioma is still unclear, which may be related to genetic factors, bad life habits, radiation environment, tumor origin and other factors. 2. Clinical symptoms: The main clinical symptoms of brain lymphoma are painless and progressive lymph node enlargement or localized lumps, which may be accompanied by systemic symptoms such as fever, night sweating, weight loss, itching and so on. The main symptoms of glioma include dizziness, vomiting, blurred vision, etc. Some patients will have seizures, which is related to the location of the tumor in the brain. 3. Scope of invasion: lymphoma of the brain may invade the opposite side of the brain tissue; while glioma of the brain may invade single or multiple lobes of the brain, but will not invade the opposite side of the brain tissue. 4. Treatment mode: The treatment mode of lymphoma of brain is based on chemotherapy and radiotherapy, and the commonly used chemotherapy drugs include vincristine, cyclophosphamide and so on. Glioma of the brain is mainly treated by surgical resection, combined with radiotherapy, chemotherapy and other therapies. The difference between brain lymphoma and glioma is different, but the diagnosis still needs to go to the regular hospital.