Lupus erythematosus combined with necrosis of the femoral head can be treated through surgical and non-surgical methods. 1. Surgical treatment: If the patient’s condition requires and the patient’s body can tolerate the surgery, patients with lupus erythematosus combined with necrosis of the femoral head can undergo surgical treatment such as artificial hip replacement. 2. Non-surgical treatment: Lupus erythematosus combined with necrosis of the femoral head with mild symptoms can be treated with medication, life care, physical therapy and other non-surgical treatments to alleviate the patient’s symptoms, the patient’s affected side should avoid weight-bearing, and if both sides are affected at the same time, it is recommended to sit in the wheelchair or bed, and high-frequency electromagnetic and other physical treatments can play a role in treating the patient’s symptoms. One of the reasons for the occurrence of femoral head necrosis in lupus erythematosus patients may be the long-term use of high-dose hormones to control lupus erythematosus disease activities, therefore, it is recommended that lupus erythematosus patients with femoral head necrosis need to comply with the doctor’s advice to reduce the amount of hormones, and in addition to comply with the doctor’s instructions for the use of cyclophosphamide, belevulinumab and other control of the disease. At the same time, oral diclofenac sodium and other analgesic treatment as prescribed by the doctor. Drugs need to be used under the guidance of a physician, it is recommended that patients with lupus erythematosus combined with necrosis of the femoral head to the rheumatology and immunology department of a regular hospital for active treatment.