Intestinal chemosis, i.e. intestinal epithelial chemosis, is a pathological change under gastroscopy, which refers to the replacement of normal gastric mucosal epithelial cells by intestinal-type epithelial cells. Severe intestinal metaplasia should be timely consultation, develop good dietary and living habits, and if necessary, choose omeprazole, thioglycollate and other medication, surgical treatment and so on. 1. Dietary adjustments: patients with severe intestinal chemosis usually need to pay attention to their diet, to ensure regular diet, with a light diet, avoid eating preserved food such as preserved fish, bacon, eat less hot pot, barbecue, fried skewers and other stimulating, greasy food, and at the same time, should quit smoking, quit drinking. 2. Life regulation: Reasonable arrangement of work and rest time, to ensure adequate sleep, avoid overwork, and maintain a good mood. 3. Drug treatment: patients with severe intestinal chemosis should follow the doctor’s instruction to use drugs for treatment, such as aluminum thioglycollate, omeprazole, cimetidine, etc. Meanwhile, gastroscopy should be reviewed regularly to observe the degree and scope of intestinal chemosis and look for possible early cancerous lesions. 4. Surgery: For patients with severe hyperplasia or extremely rapid development of the disease, surgery is needed as soon as possible to remove the lesions. Patients with severe intestinal metaplasia should go to the hospital in time to find out the cause of the disease and actively cooperate with the doctor’s treatment.