Gastric mucosa granularity is mostly caused by gastritis, mostly seen in chronic atrophic gastritis. Gastric mucosal granularity is a description of the results of the gastroscopy, refers to the gastroscopy examination, found that the surface of the gastric mucosa is not smooth, but fine granular, mostly due to inflammation caused by stimulation, mostly in chronic atrophic gastritis, the patient will often appear repeated abdominal pain, bloating, heartburn, acid reflux and other symptoms. If H. pylori infection does not occur, it is often relieved by taking gastric mucosal protective agents, such as bismuth potassium citrate and aluminum thiosulfate. If H. pylori infection is present, quadruple therapy is required, i.e., a proton pump inhibitor, a bismuth agent and two antibiotic drugs, e.g., omeprazole, bismuth pectin, clarithromycin and metronidazole. Gastric mucosa particles induction to further clarify the diagnosis, determine the treatment plan, and actively cooperate with the doctor for treatment.