The importance of cranial bone is self-evident, however, many people in life have cranial defects for one reason or another, which seriously affects the aesthetics and is a great harm to their health. Cranial defect is a big problem, patients must pay attention to it, and it is important to go to the hospital for cranial repair surgery as early as possible. Only through cranial repair surgery can the integrity of the skull be restored and bigger problems be avoided. When it comes to skull repair surgery, the key point is the choice of repair material, only good material repair effect will be better. At present, titanium mesh material is widely used in medicine, so what about titanium mesh material for skull repair? 1, after the skull titanium mesh repair, must pay attention to avoid infection, to avoid collision injury again, because the hardness of titanium mesh material is not very strong, in some strong collision and impact will lead to deformation. 2, after the surgery, can not be exposed to the sun, otherwise it will lead to a significant burning sensation of the patient’s scalp, affecting the results. In addition, it is also not advisable to stay in too cold environment. 3, titanium mesh repair skull after, must not do some more strenuous sports, such as bungee jumping and so on. 4, titanium mesh is a metallic material, after the surgery can not do CT MRI, because it will lead to artifacts in the examination results, affecting the diagnosis. Obviously, there are still many contraindications to using titanium mesh material for skull repair surgery, and there are also many defects. Therefore, it is no longer recommended to use titanium mesh for skull repair surgery. There is a new type of material that can be used, and that is peek material, which is comparable to human cranial bone, and the postoperative results are quite good, and there is no need to worry about any adverse reactions or sequelae. This PEEK cranioplasty can achieve the organic unity of anatomical integrity, functional perfection, and aesthetic appearance with remarkable results. With 3D printing, it is comparable to autologous cranial bone and is the preferred cranial bone repair material for patients.