Bartter syndrome is a group of rare inherited glomerular disorders. The patients have abnormal sodium chloride reabsorption function in the thick segment of the ascending branch of Henle’s collaterals and distal tubules.
1. Clinical symptoms: polydipsia, polyuria, salinophilia, dehydration tendency, recurrent vomiting, constipation, intermittent limb pain, limb weakness, convulsions, palpitations, decreased appetite, growth retardation, intellectual developmental disorders, and so on.
2. Seriousness: Some patients with infantile onset of symptoms are accompanied by mental retardation; adults without active treatment can lead to osteoporosis, and persistent hypokalemia and hypernephrinemia can lead to progressive tubulointerstitial nephritis, which can lead to end-stage renal failure. In the absence of effective treatment, the condition may be fatal.
3. Treatment: The treatment of Bart’s syndrome is mainly aimed at controlling symptoms and avoiding serious complications. Potassium supplementation can be prescribed by doctors, such as long-term high-dose oral potassium chloride to correct hypokalemia, and spironolactone, aminopterin and other drugs under the guidance of doctors for treatment.
4. Dietary attention: patients should eat less or spicy and stimulating food, such as chili, onion, mustard, etc., avoid taking greasy and fried food, quit smoking, alcohol, coffee and other excitatory beverages.
This disease is a genetically inherited disease, active prenatal testing may reduce the risk of Bartter syndrome.