A quadruple therapy consisting of bismuth + PPI + 2 antibacterial drugs is recommended. There are 4 antimicrobial drug regimens: 1) amoxicillin + clarithromycin; 2) amoxicillin + levofloxacin; 3) amoxicillin + furazolidone; 4) tetracycline + metronidazole or furazolidone. For penicillin allergy The recommended antibacterial drug composition regimen is: 1. clarithromycin + levofloxacin; 2. clarithromycin + furazolidone; 3. tetracycline + metronidazole or furazolidone; 4. clarithromycin + metronidazole. Regimen Given that a longer course of bismuth quadruple therapy may improve the efficacy to some extent, the recommended regimen is 10d or 14d, and the 7d regimen is abandoned.