Patient: My father, 63 years old, was admitted to Hengyang First Hospital with diarrhea in August last year and was found to have enlarged mediastinal lymph nodes, about the size of a bean. No fever, no cough, no sputum. No chest tightness or shortness of breath. No special treatment was done. At that time, the doctor said it was benign. It was recommended to review in a few months. By the year before. My father started to notice pain in the upper part of his chest and took him for a checkup. Since my father said it was going to be the New Year. He said he would go back after New Year’s Eve for a checkup, but he was negligent at the time. Until the first month 16 after the New Year, and then go to the attached one to do a CT examination found mediastinal lymph nodes of egg size, do left shoulder different enlarged lymph biopsy, no signs of malignancy, such a film to Xiangya attached one hospital examination, confirmed as vascular slip. Father’s pain increased. He stayed in Xiangya Hospital for 10 days with no sign of improvement. Then he was transferred to the Department of Hematology of Xiangya Hospital. A swollen lymph biopsy was performed again on the right side of the neck. Still no sign of malignancy. Then the doctor tried to administer 1/4 dose of chemotherapy drugs. It did not work. The mass kept growing. Again CT has 9.9X9.5X10.1CM size soft tissue density foci. The borders were clear and the density was homogeneous, and the CT value was about 28 HU on plain scan, and mild marginal enhancement was seen on enhanced scan. The lesion reached upward to the entrance of the chest and downward to the level of the pulmonary hilum. The distal part of the bronchus in the right upper lobe was narrowed by compression, and multiple enlarged lymph nodes were seen in the right hilar of the lower neck in the posterior mediastinum; the two lung textures were clear, and a small amount of cord-like fiber shadow was seen in the right lower lobe. The bronchi of each lobe were clear, and no signs of dilatation or obstruction were seen. The right pleural cavity was seen to be filled with fluid. Diagnostic imaging: right upper mediastinum occupying lesion with multiple lymph node enlargement in the neck and right hilum, and superior vena cava invasion, right pleural fluid. Old right lung lesion (09-2-24) (needle aspiration smear of right supraclavicular node) A few inflammatory cell fibers and adipocytes were seen, no malignant cells were seen. (09-3-6) Frozen + paraffin (right neck) sent for lymph node examination results in the presence of lymph sinuses partially replaced by capillary-like spaces in which are red blood cells, considered as lymph node angiomatosis, no malignant lesions were seen in the sent tissue. The hematologist was at his wit’s end and asked the entire hospital to consult with him. Since my father had 8 years of hypertension and 3 years of diabetes. He could not be removed surgically (the time for removal was already missed), and he kept coughing. It was compressing the breathing organs. Unable to lie flat. He sat on the edge of his bed 24 hours a day and coughed, which was very painful. Then he was transferred to the oncology department. It was prepared to be removed by argon helium knife. But it could not be performed either. With no other viable option. A new drug, Endo, was used. The doctor said that if this drug does not work after one course of treatment (14 days, now on day 9), maybe my father will be suffocated alive. I would like to ask all the kind doctors to help me. My father has been unable to eat, sleep or lie down for the past 10 days, and he keeps coughing but he can’t cough. He can only sit, and in the second half of the night, he is in even more pain, sweating all the time, and the pain is so severe that he has taken several painkillers to no avail. It was really painful. Oxygen saturation is less than 90, please help him. Doctor: “Doctor tries to use 1/4 dose of chemotherapy drug”, the chemotherapy dose is too small. Chemotherapy regimens for tumors of unknown primary site can be tried. It is better to get the pathological diagnosis of tumor by surgery or CT or ultrasound guided puncture. If the physical condition is very bad, then it depends on the efficacy of Endo, or palliative care.