H. pylori can be completely eliminated by triple therapy or quadruple therapy. Triple therapy is two antibiotics plus a proton pump inhibitor, and the antibiotics are often penicillins, macrolides, quinolones, and nitroimidazoles, and the acid inhibitors are often omeprazole, rabeprazole, and pantoprazole. The triple therapy of amoxicillin plus clarithromycin plus rabeprazole is often used clinically for anti-H. pylori treatment with a course of 10-14 days, which can completely eliminate H. pylori in most cases. However, a small number of patients have drug resistance and other reasons for treatment failure, then you should change the antibiotics and add bismuth, such as colloidal bismuth pectin, bismuth aluminate, etc. to kill H. pylori again.