Itchy red spots on the calves are common in eczema, contact dermatitis, urticaria and other diseases, need to target specific diseases, choose the appropriate drug treatment, commonly used drugs include antihistamines, glucocorticoids, antibiotics and so on. 1. Eczema: obvious itching, can be used externally to stop itching agent treatment, such as glycerine lotion, zinc oxide ointment, etc.; inflammation is more serious, external glucocorticoid treatment, such as hydrocortisone cream, etc.; secondary infection, external antibiotic treatment, such as mupirocin ointment, etc.; itching is serious, oral antihistamine treatment, such as loratadine, etc.. 2. Contact dermatitis: local symptoms are mild, can be used externally phenol, menthol and other drugs; symptoms are more serious, oral antihistamine treatment, such as Benadryl, cetirizine, etc.; extensive lesions, oral glucocorticoid treatment, such as prednisone, etc.; complications, oral antibiotic treatment, such as erythromycin. 3. urticaria: usually need to use antihistamines in time, such as ibastine, loratadine, etc.; the more serious condition, the use of glucocorticosteroid treatment, such as dexamethasone, etc.; if accompanied by angioedema, the need to inject adrenaline treatment. It is recommended that patients should follow the doctor’s instructions after a clear diagnosis, and should not blindly self-medication, so as not to produce adverse reactions, affecting the treatment.