Doxycycline ophthalmic ointment is a compounded formulation whose main active ingredients include tobramycin and dexamethasone. It may also cause adverse reactions or side effects, both from the hormonal component and the anti-infective component, including itching of the eyelids, edema, and conjunctival congestion, which typically occur in less than 4% of patients. In addition, it may cause adverse reactions related to the hormonal component, including increased intraocular pressure, glaucoma and occasionally damage to the optic nerve, delayed wound healing, and secondary infections in patients treated with both antibiotics and hormones. In conclusion, the side effects of D&C ophthalmic ointment can be derived from two sources: tobramycin, an antibiotic, and dexamethasone. If you experience any discomfort during use, you should stop using this medication and consult your doctor or pharmacist promptly.