Pediatric lacrimal duct obstruction is a common condition in infancy, mostly within the first month of life. The main manifestations are lacrimation or tears in the eyes and mucus overflow from the eyes. It can develop in one or both eyes. The main cause is postnatal obstruction of the lower nasolacrimal duct (the duct that drains tears). If there is no secondary infection, only clear or translucent mucus will spill out of the corner of the eye in addition to tears. In this case, there is no need to use “anti-inflammatory eye drops”, i.e. antibiotic drops, and there is no need for systemic antibiotics. When there is secondary infection or acute inflammation of the eye; or chronic purulent inflammation with pus outflow and conjunctivitis, antibiotic drops or even systemic antibiotics should be used. The use of antibiotic eye drops for infants should be preservative-free, less irritating and sensitive. They should not be applied continuously for a long time after the inflammation is controlled; they do not cure tearing. Infections often occur due to inaccessible tear ducts, and early opening of the tear ducts so that tear drainage is unobstructed is the fundamental treatment.