There is no research on the greatest harm of Phellodendron Bark. Phellodendron Bark has the effect of clearing heat and drying dampness (removing heat and drying dampness), removing fire and vapor, detoxifying and healing sores, and is often used in damp-heat diarrhea (diarrhea caused by feeling damp-heat), jaundice, and subluxation. Phellodendron Bark is the dried bark of Phellodendron Bark or Phellodendron Bark of Rutaceae plant, which belongs to the heat-clearing and dampness-clearing medicine. Phellodendron Bark enters the bladder meridian and kidney meridian. Phellodendron Bark is bitter and cold in flavor. Phellodendron Bark can be used internally and externally. Phellodendron Bark has the effect of clearing heat and drying dampness, removing fire and steam, detoxifying and healing sores, and is used in the treatment of spermatorrhea, damp-heat diarrhea and dysentery, night sweating (sweating abnormally after falling asleep and stopping sweating after waking up), jaundice, laborious heat in bone vapor, dysentery, sores and swollen poisons, athlete’s foot, heat drenching (burning and tingling during urination, accompanied by frequent and urgent urination, and discomfort of abdominal traction), and itching of eczema. Phellodendron Bark is cold in nature, and should be used with caution in cases of coldness of the spleen and stomach (spleen and stomach weak and cold), loose stools (thin and unformed feces) and diarrhea. The adverse effects of Phellodendron Bark are not known. If needed, please use under the guidance of a professional Chinese medicine practitioner.