Syphilis and eczema are two different diseases that can be distinguished from each other in terms of etiology, clinical manifestations, pathogenesis, and treatment principles. 1. Etiology: syphilis is a chronic, systemic sexually transmitted disease caused by syphilis spirochete infection, the main cause of the history of unclean sexual intercourse. Eczema is an inflammation of the superficial dermis and epidermis caused by a variety of internal and external factors, the cause of which is still unclear. 2. Clinical manifestations: Stage I syphilis manifests as genital chancre; Stage II syphilis manifests as red papules and blotchy rash on the skin, i.e. syphilis rash; Stage III syphilis manifests as nodular syphilis rash and dendritic swelling. Eczema is mainly manifested as a polymorphic skin rash, with oozing in the acute stage and mossy changes in the chronic stage, symmetrically distributed and accompanied by intense itching. 3. Morbidity characteristics: early syphilis is highly contagious, but timely intervention can be cured, late syphilis is highly destructive, can make the body disabled and dementia, and even life-threatening. And eczema is not infectious, but easy to recur. 4. Treatment: penicillin is preferred for syphilis to drive plum treatment, while eczema needs anti-inflammatory and anti-allergy treatment. If you have any symptoms of physical discomfort, you should go to the hospital and consult a physician for guidance.