Usually, when diuretic treatment is given or the patient has some related disease, potassium ions can be disordered. What kind of effects can potassium ions cause? 1. Skeletal muscle damage: Potassium has a regulatory effect on the blood flow in skeletal muscle. Here is a very important point. An increase in the concentration of potassium in the intercellular fluid can cause vasodilation. The catecholamine beta-2 receptors increase the activity of the sodium-potassium pump to regulate this process. In hypokalemia, the potassium concentration in the intercellular fluid decreases, thus reducing the release of potassium from skeletal muscle during exercise. 2, renal damage: hypokalemia, due to the potassium conservation properties of the renal tubular epithelium, inevitably leads to a decrease in potassium-sodium exchange and thus an increase in sodium-hydrogen exchange, when the activity of the sodium-potassium pump is correspondingly weakened, thus morphologically showing swelling and hyperplasia of the epithelial cells and a decrease in responsiveness to ADH, with similar interstitial nephritis-like manifestations. Functionally, it shows polyuria due to impaired urine concentration. 3, abnormal acid-base balance: low potassium and low chloride alkalosis, which is a phrase we often remember when we study for the exam. The main reason is due to the transfer of hydrogen and potassium inside and outside the cell and the increased exchange of sodium and hydrogen at the renal tubules, there will also be paradoxical acidic urine. Therefore, it is particularly important to monitor potassium ions in patients undergoing diuretic therapy in clinical practice.