There are many kinds of potassium channel blockers, a compound that inhibits the passage of potassium ions through membrane channels. The main effect is that it can inhibit smooth muscle cells, neuroma cells, and the low-charged potassium channels in the membranes of hepatocytes. In clinical practice, they are mainly divided into a variety of drugs, the most common of which are amiodarone hydrochloride, which can affect the metabolism of the thyroid gland and treat endocrine diseases, and then sulfonylurea hypoglycemic drugs, such as glibenclamide and gliclazide. Potassium channel blockers can dilate coronary vessels, increase coronary blood flow, reduce myocardial oxygen consumption and slow down heart rate, and treat supraventricular atrial fibrillation and tachycardia. Potassium channel blockers can also increase calcium inflow and increase myofiber contractility, thus treating diseases such as myocardial weakness. Potassium channel blockers have specific potassium channel blockers that can treat and prevent arrhythmias.