There are two reasons why newborns spit up all the time: one is a normal physiological phenomenon, i.e., newborn milk spillage, which is mainly related to the newborn’s stomach being horizontal, cardia relaxation and pyloric spasm. As the age of the newborn increases, this situation will gradually improve. Another situation is the pathological factors cause newborns to spit up, that is, in the disease state cause newborns to spit up, common congenital hypertrophic pyloric stenosis, neonatal infections, neonatal intestinal inflammation, neonatal intestinal obstruction, and newborn congenital intestinal developmental malformations, such as intestinal atresia, anus atresia, etc., may lead to newborns to spit up. If it is clear that the newborn is not spilling milk but spitting up, we should go to the hospital in time to find the cause of newborn spitting up, and do the appropriate treatment in order to completely improve the newborn spitting up, otherwise it will affect the growth and development of newborns.