Hyaluronic acid, also known as hyaluronic acid, is secreted by fibroblasts in the dermis and can be obtained through large-scale industrial production. Hyaluronic acid injections can fill and smooth out the depressed part of the lines, thus achieving the effect of getting rid of the lines, and the effect is natural and safe. Injections of hyaluronic acid to get rid of frown lines do not cause problems under normal circumstances. However, there are major blood vessels supplying the nose and face in the area, if the injection level is not well mastered and the injection technique is not paid attention to, it may lead to hyaluronic acid mistakenly entering the blood vessels, causing vascular embolism, which can be manifested as necrosis of the skin of the nose, loss of vision due to ophthalmic arterial embolism, and cerebral infarction caused by cerebral vascular embolism, or even life-threatening. In addition, the injection should also be closely observed, once the skin color change occurs, early intervention should be dealt with, generally within 6 hours with lysosomal enzymes for dissolution can be relieved. Vasodilator drugs (e.g., Salvia divinorum or 654-2 injection) are also used. This procedure is recommended for experienced physicians, and the hyaluronic acid lasts for 6-10 months after injection. If the effect needs to be maintained, it can be re-injected with 1-2 injections. However, for severe lines accompanied by skin laxity, the effect of hyaluronic acid injection is often unsatisfactory, and can be removed using thread sculpture or facelift surgery.