Normal total bilirubin ranges from 1.7 to 17.1 μmol/L. The total bilirubin of 27 μmol/L is a little high, and it is necessary to combine with the patient’s condition to determine whether it is physiologically high. If it is pathologically high, attention should be paid to it and active intervention should be carried out. 1. Physiological high total bilirubin: newborns are prone to physiological jaundice, which occurs 2~3 days after birth and usually subsides within 7~10 days. During this period, the total bilirubin will be high and usually there are no other uncomfortable clinical symptoms, so no special treatment is needed. 2. Pathologically high total bilirubin: consider viral hepatitis and biliary obstruction. (1) Viral hepatitis: mainly manifested as loss of appetite, anorexia, hepatitis B patients can be treated with nucleoside analogs, such as lamivudine, entecavir, etc. Hepatitis C patients are recommended to use antiviral drugs directly, such as sofosbuvir, dalatasvir and so on. (2) Biliary obstruction: when accompanied by infection, antibiotics can be used for anti-inflammatory treatment, such as cefoxitin, cefixime, etc.; adenosylmethionine can also be used to improve the condition as prescribed by the doctor. The total bilirubin is elevated, it is recommended to standardize the treatment under the guidance of regular medical institutions and professional doctors, so as to avoid delaying the condition. Drugs need to be used under the guidance of a professional physician, and should not be used arbitrarily.