Angina pectoris is a group of clinical syndromes of angina pectoris caused by inadequate coronary blood supply, which is a contradiction between the blood supply of the coronary arteries and the blood demand of the myocardium, and when the coronary blood flow cannot meet the metabolic needs of the myocardium, causing acute and temporary ischemia and hypoxia of the myocardium. Angina is often manifested as pain in the anterior thoracic region, mainly located in the retrosternal or precordial region, and radiating to the left shoulder and left forearm, and so on, which can explain the many different types of angina. So, what are the causative factors of anterior chest compression pain? The following is a brief description: The controversy over the pathogenesis of angina pectoris, which is still inconclusive, dates back to the beginning of this century. colbeck proposed more than 80 years ago that the pain of myocardial ischemia is due to the stretching of the ventricular wall (i.e., the mechanical hypothesis), and 20 years later, Lewis suggested that the pain is related to the local release of certain substances from the myocardium (i.e., the chemical hypothesis). These two schools of thought have been debated for decades, and it now seems unlikely that the mechanical hypothesis can explain angina pectoris; instead, the chemical hypothesis has been confirmed by experiments. It has been demonstrated that the pain-causing substances produced by myocardial ischemia and hypoxia are adenosine, lactate, potassium ions, hydrogen ions and plasma kinins. The receptors of the heart are mainly sympathetic nerve endings, which are much less numerous than somatic receptors on the visceral organs and are mainly distributed in the proximal part of the small coronary arteries. When ischemia and hypoxia occur in the myocardium, the metabolic nociceptive substances produced locally stimulate these receptors and trigger nociceptive nerve impulses, which are transmitted through the 1st-4th thoracic sympathetic ganglia to the corresponding spinal cord segments, and through the afferent nerves to the cerebral cortex to produce pain. Since the nociceptive sensation produced by the viscera is often reflected in the skin area distributed by the spinal nerve in the corresponding segment of the spinal cord, the pain reflected in angina is often in the anterior thoracic region, mainly located in the retrosternal or precordial region, and radiating to the left shoulder and left forearm, and so on, which can explain the many different types of angina. Mechanical stimulation of the heart does not cause pain, but myocardial ischemia and hypoxia do. Angina pectoris occurs when there is a conflict between coronary blood supply and myocardial blood demand, and coronary blood flow cannot meet the metabolic needs of the myocardium, causing acute, temporary ischemia and hypoxia of the myocardium.