Strong echogenic dots in the gallbladder wall with comet’s tail sign is a description of the condition of the gallbladder wall by ultrasound, which refers to the calcification of the gallbladder wall, and has a certain suggestive effect on chronic cholecystitis. Clinical screening of the gallbladder by ultrasound can visualize the condition of the gallbladder wall, and in the process of examination, it is found that there are some abnormal echoes in the gallbladder, which are strong echoes with posterior acoustic shadows, and they will be described as strong echogenic dots with comet’s tail sign, which is a kind of descriptive diagnosis of calcification of gallbladder wall, and a large part of the corresponding condition is correlated with chronic cholecystitis. In combination with the clinical history, if there are symptoms of recurrent right upper abdominal pain and discomfort, and a history of acute cholecystitis, chronic cholecystitis will be considered as a whole, and surgical resection can be performed under the guidance of the clinician if necessary.