Tic disorders (TD) were first described by Itard (1825) and then first reported by Gilles de la Tourette (1885), and are neuropsychiatric disorders characterized by motor tics and/or vocal tics, mostly starting in adolescence. It is a common neurodevelopmental disorder and is often associated with ADHD in children, with a reported co-morbidity rate of more than 50%. The main clinical manifestation is involuntary, repetitive, rapid, purposeless motor or vocal twitching of one or more muscles, which can be accompanied by many behavioral problems, such as nail biting, nose-picking, and hyperactivity. The age of onset is 2 to 21 years old, with more males than females, and the ratio of males to females is 3 to 5 : 1. It is most common in preschool and school-age children, with 5 to 10 years old being the most common. The condition is usually most severe between the ages of 10 and 12. Tic symptoms usually begin in the face and progress to the head, neck, and shoulder muscles, and then spread to the trunk and upper and lower extremities. The twitching can take various forms, including motor or vocal twitches. The frequency and intensity of twitches fluctuate during the course of the disease, and new twitching symptoms may replace the old ones, or new twitching symptoms may appear on the basis of the original ones, often aggravated or alleviated by stress, fatigue, mood swings or physical discomfort or illness, or may remit temporarily or spontaneously for a long time. About half of tic disorders are associated with one or more psychological and behavioral disorders, such as attention deficit hyperactivity disorder, learning difficulties, obsessive-compulsive disorder, sleep disorder, mood disorder, self-injurious behavior and conduct disorder, which seriously affect the development of children and adolescents’ learning, social adaptability, personality and psychological quality. According to the clinical symptoms and duration of the disorder, tic disorders are divided into three types: transient tic disorder, chronic tic disorder and Tourette syndrome (TS), the prevalence of which is 5%-7%, 1%-2% and 0.1%-0.5% respectively. Transient TD is the most common type of TD and the mildest type, which is characterized by one or more motor tics and/or vocal tics with a duration of less than one year. TS, also known as multiple tics, is a relatively severe form of tic disorder, with both motor and vocal tics, but not necessarily both, and with a duration of more than one year. Recent reports in the literature show an increasing trend in the incidence of TD. A recent survey of school-age children showed that 18% of children had tic disorders, of which 3% met the diagnostic criteria for TS. It is currently believed that tic disorders may be due to neurotransmitter abnormalities, such as hyperdopaminergic neurotransmission, dysfunction of serotonin (5-HT), or reduced inhibition of γ-aminobutyric acid (GABA) in the brain. Therefore, the drugs used to treat tic disorders usually act on the brain neurotransmitters to restore them to normal function. The main types of drugs commonly used to treat tic disorders in children are the following. Antipsychotic drugs, adrenoceptor agonists, antiepileptic drugs, etc. The more widely used α-adrenoceptor agonist, Clonidine transdermal patch, has been used as a first-line drug for the treatment of moderate tic disorders in children and adolescents due to its high safety, obvious efficacy, and ease of use. Clonidine is also often used to treat children with co-occurring attention deficit hyperactivity disorder and obsessive-compulsive disorder. Colistin is effective in reducing tic symptoms and has shown significant efficacy in both motor and vocal tics, as well as in the treatment of combined impulsivity and hyperactivity. Other antipsychotic drugs, such as haloperidol, thiopride and some atypical antipsychotics such as aripiprazole and risperidone, are also widely used clinically with significant efficacy and good therapeutic effects, but their clinical use is also limited by the fear of many parents of taking western drugs due to some adverse effects and individual differences. Anti-epileptic drugs are not promoted as first-line drugs.