Pituitary tumor larger than 4 centimeters can be operated, and it is recommended that patients seek medical treatment as soon as possible. Pituitary tumor is a benign tumor originated from adenopituitary gland and neuropituitary gland, etc. Clinically, according to whether the tumor has the function of hormone secretion, it is divided into functional pituitary tumor and non-functional pituitary tumor, and according to whether the size of the tumor is more than 1cm, it is divided into microadenoma and macroadenoma. First of all, as the tumor diameter is larger than 4 centimeters, it belongs to the category of macroadenomas. Even non-functional pituitary tumors usually cause occupying effect due to occupying and compression of surrounding tissues. If the diameter of functional pituitary tumor is larger than 4 centimeters, the condition is usually more serious and patients need to seek medical treatment as soon as possible. At present, the commonly used clinical surgery is transnasal pterygoid microsurgery, which is a minimally invasive surgery, and the patient will recover faster after the surgery. Secondly, if the patient’s pituitary tumor has already invaded the suprasaddle and pars pallidus, the patient usually needs to be treated by transfrontal craniotomy. There are many types of pituitary tumors known to the clinic, of which all except prolactinoma can usually be treated by surgery. Prolactinomas are usually microadenomas, usually less than 1 centimeter in diameter, so most pituitary tumors larger than 4 centimeters can be operated on. It is recommended that patients with pituitary tumors larger than 4 centimeters should seek timely medical treatment under the guidance of their doctors to avoid delays.