Prednisone can be taken at the same time with sartan antihypertensive drugs, known data show that the two do not affect each other, but the specific use of drugs should be strictly in accordance with medical advice. Prednisone is a glucocorticoid, mainly used for allergic and autoimmune inflammatory diseases, such as systemic lupus erythematosus, severe bronchial asthma, dermatomyositis, vasculitis and so on. Its adverse reactions are infection, intracranial pressure, peptic ulcer, class Cushing’s syndrome, etc. It is prohibited for those who are allergic to the product, patients with systemic mycobacterial infections, and should be used with caution in patients with diabetes mellitus, hypertension, and other relatively high-risk groups. Sartan antihypertensive drugs include valsartan, chlorosartan, timosartan and so on. Valsartan, for example, is mainly used to treat mild to moderate essential hypertension. Its adverse reactions include cough, abdominal pain, dizziness, fatigue, etc. It is prohibited for those who are allergic to valsartan and pregnant women. Prednisone and sartan antihypertensive drugs do not interact pharmacologically, and when the indications for both are met and contraindications are ruled out, the two drugs can be taken at the same time in accordance with the physician’s instructions. If significant discomfort occurs after combined use, consult a physician.