How to treat endometrial cancer patients to preserve their fertility?

  Endometrial cancer commonly occurs in postmenopausal women, while 20% to 25% of cases occur in premenopausal women and about 5% of cases occur in women of childbearing age under 40 years. The main treatment for endometrial cancer is total hysterectomy with both adnexa or simultaneous retroperitoneal lymph node dissection. In young endometrial cancer patients, surgery has a direct impact on quality of life. Most young patients with well differentiated early-stage endometrial cancer are effective in hormonal therapy, therefore, treatment with preservation of fertility function is feasible and necessary.  Indications for preserving reproductive function in endometrial cancer Conservative treatment should be performed only for patients with a strong requirement for preserving reproductive function. Before treatment, a comprehensive assessment of the presence of myometrial infiltration and extra-uterine disease should be performed, and patients should be informed in detail about the advantages and disadvantages of conservative treatment and sign an informed consent form Conservative treatment for endometrial cancer is not recommended in the guidelines of authoritative institutions such as FIGO. After a thorough pre-treatment evaluation, only patients who meet all of the following criteria should be considered for fertility preservation treatment