Most endometrial cancers are caused by estrogen We know that most endometrial cancers are caused by the unbridled presence of estrogen in the body. This is because estrogen can constantly stimulate the endometrial lining to grow while lacking the action of progesterone to help it shed (menstruation formation). In this way, the prolonged presence of thickened endometrium provides the conditions for the formation of endometrial cancer. Most of the women have mutations of the endometrium due to their own endocrine factors or long-term abuse of drugs and supplements containing estrogen. This kind of endometrial cancer is also called “estrogen-dependent endometrial cancer”, which accounts for 80% of all endometrial cancers, but the treatment effect is generally better. For young patients who have not yet had children, they usually want to save their ovaries. And a large percentage of them have polycystic ovary syndrome (polycystic). One of the main features of polycystic ovary syndrome is the absence of ovulation, which means that there is no progesterone production and therefore no menstruation or menstruation only comes once in a while. However, fortunately, polycystic patients are usually found to have less extensive cancer and are in the early stages of stage 1A. We can send progestin to counteract estrogen. For the treatment of stage 1A endometrial cancer patients, the endometrial cancer lesion can be removed under hysteroscopy first. The patient is then given a highly effective progestin, and the endometrium begins to peel off in response to the progestin to produce menstruation. After several menstrual cycles, the endometrial lining is renewed and the disease can usually be reversed in most patients. After the tissue structure of the endometrium returns to normal, it is best for the patient to get pregnant as soon as possible (after pregnancy, the endometrium will not grow anymore and the ground for endometrial cancer growth will be cut off). For polycystic patients who have difficulties with ovulation themselves, they can go to a fertility center to help them conceive after progestin treatment. However, it is important to remind all patients who are treated with progestins: it is important to review them for a long time after the end of treatment, whether they get pregnant immediately or not. This is because many patients experience a relapse after they have given birth. Particular attention should be paid to patients who are obese themselves, have polycystic ovaries, do not ovulate or are insulin resistant.