Aspiration in newborns should be done with strict attention to aseptic operation to avoid cross infection. Aspiration for newborns is done by professional medical staff of neonatal department. The suction tube should be changed after each suction, the suction tube must be kept sterile, the airway should be suctioned first and then the oral and nasal secretions, and the opened packet of saline should indicate the date and time of opening and discarding, and be hung at the bedside of the child for one person. If the sputum is sticky and blocked to the catheter not easy to be sucked out during suction, you can pat the newborn’s back to promote sputum sucking out by vibration or carry out nebulized inhalation and suck out after sputum dilution. For children with long-term sputum sucking, continuous oxygen-driven nebulization is given to turn over and pat the back before routine sputum sucking, and the method of patting the back is from bottom up and from outside to inside, using wrist power to drive arm power and avoiding the scapula and spine. Generally, the duration of aspiration should not be longer than 15 seconds, so as not to cause asphyxia, and the suctioning technique should be light so as not to damage the mucous membrane of the mouth, nose and trachea. The suction tube should not be inserted too deeply and avoid upward and downward lifting and inserting.