Intractable headaches, more common in clinical practice, are primary headaches, especially migraines. Migraine treatment in the attack period, if the attack is infrequent, you can take ordinary non-steroidal anti-inflammatory drugs, such as ibuprofen, aspirin, indomethacin class of drugs; some patients, such as the pain is more severe. You can also choose ergot alkaloids or tretinoin, such as zolmitriptan, rizatriptan, because it is actually a vasoconstrictor, the pathogenesis of migraine, the first is vasoconstriction, and then secondary vasodilatation, so the tretinoin is actually blocking vasodilatation, and then to achieve the effect of pain relief, so it is relatively speaking, is a more effective drug, but because of the consumption of more of this vasoconstrictor, can have a risk, so do not take more.