The side effects of intra-articular injection have a great relationship with the operation, such as improper operation can easily lead to the following side effects: 1, cause intra-articular infection, mostly due to improper aseptic operation; 2, damage to the neurovascular, or mistakenly inject the drug into the blood vessels, intra-articular injection needs to choose the appropriate entry point, avoiding the main blood vessels and nerves. During the puncture process, the patient’s reaction should be closely observed, and if neurological symptoms occur, the injection should be stopped immediately. After puncture into the joint cavity, observe the color of the retracted fluid, if it is red, it means that the blood vessels have been injured, and the position of the needle should be reversed and the injection point should be selected again; 3. The tip of the needle injures the intra-articular cartilage. This is the injection position is too deep, into the joint cavity, continued deep injury to the cartilage surface; 4, drug side effects caused by complications, joint puncture drugs for local application, but with the oral and other modes of medication, the joint effect on the human body may still occur when the interaction. Therefore, before the joint cavity injection, you should inform the doctor in detail about the drugs you have taken recently, and let the doctor judge whether to carry out the drug joint cavity injection or not. Therefore, the choice of intra-articular injection therapy has a high demand on the operation technology and operating environment, and must choose a regular hospital for treatment.