There are more tacrolimus preparations, and the commonly used clinical dosage forms include ointment, capsule, extended-release capsule, eye drops, and injection. Tacrolimus ointment, can be used in the treatment of vitiligo. However, simply using tacrolimus ointment treatment, the effect is not very satisfactory. Tacrolimus is an immunosuppressant, which is mainly used to prevent graft rejection reaction after liver and kidney transplantation, and can also be used to treat graft rejection reaction after kidney and liver transplantation that cannot be controlled with other immunosuppressant drugs. Spring keratitis and conjunctivitis, ineffective by anti-allergy treatment, can also be given this drug treatment. The cause of vitiligo has not been fully clarified, and it can occur anywhere on the body, especially in areas that are susceptible to friction or sunlight exposure. The treatment of vitiligo mainly includes topical hormonal ointments and calcium-modulated neural phosphatase inhibitors, such as tacrolimus ointment and pimecrolimus cream, which can restore the color of some of the skin. Adverse reactions such as burning sensation on the skin, itching, and flu-like symptoms may be experienced after use of the drug, and the product is contraindicated in patients with a history of hypersensitivity to tacrolimus or any other ingredient in the preparation. Note that tacrolimus ointment should not be used in immunocompromised adults and children. Do not apply tacrolimus ointment continuously for a long period of time. Patients with vitiligo are advised to visit the dermatology department of the hospital and be given appropriate medication under the doctor’s guidance. You should also read the instructions in detail before using the drug to understand the adverse reactions and contraindications of the drug.