Betel nut is native to Malaysia and mainly distributed in tropical areas such as Yunnan, Hainan and Taiwan in China. After chewing betel nut, people often eat betel nut to protect themselves from cold and eliminate fatigue after stressful work. At present, people mainly in Hainan, Taiwan and Hunan enjoy betel nut. Our traditional medicine believes that betel nut has the effect of expectorant and cough, eliminating food and alcohol, broadening the chest and stopping vomiting, repelling worms and treating abdominal distension, etc. Modern research has found that the active ingredients in betel nut have the effect of repelling worms and parasympathetic nerves, etc. Long-term consumption of betel nut alkali causes salivation, vomiting, diuresis, drowsiness and convulsions, respiratory difficulties. In betel nut chewing patients, the early manifestations are mostly tooth discoloration, dry mouth, loss of taste, gum congestion, rapid tooth wear, etc.; in addition, due to the hardness of betel nut, long-term betel nut chewing will increase the burden on the temporomandibular joint, gradually appearing temporomandibular joint disorder symptoms, such as joint popping pain and other symptoms, such as further development, difficulty in opening the mouth, swallowing difficulties, etc. Some lesions will gradually develop into oral cancer, appearing local ulceration, lymph node metastasis and distant organ metastasis. Early stage fibrosis, middle and late stage fibrosis, cancerous transformation According to the research results of domestic medical institutions over the past few years, more than half of the patients with oral cancer have the habit of betel nut chewing. If betel nut chewing is combined with smoking, it is more likely to cause oral cancer, laryngeal cancer, pharyngeal cancer and esophageal cancer. As early as 2003, the International Agency for Research on Cancer put betel nut on the “blacklist”, which is classified as a first-class carcinogen along with tobacco, alcohol and arsenic. Betel nut contains a large amount of betalains and alkaloids, which are cytotoxic, and the reaction between oral mucosa and alkaloids contained in betel nut will lead to fibrosis of oral mucosa. Hunan Province has the highest incidence of oral cancer in the world! Betel nut, despite its medicinal value, can be completely replaced by known drugs, and in view of its strong carcinogenicity, it is strongly recommended that we stay away from betel nut.