The hepatitis B vaccine is a special drug used to prevent hepatitis B disease and consists of purified hepatitis B surface antigen, which has the purpose of preventing hepatitis B infection. Hepatitis B is a chronic hepatitis that can lead to cirrhosis and then to hepatocellular carcinoma, and should be prevented as early as possible. The hepatitis B vaccine is administered by intramuscular injection and requires an adjuvant at the time of vaccination, which can be combined with other vaccinations for infants, such as diphtheria-tetanus-pertussis and inactivated polio vaccine. For children, adolescents and adults, three doses of hepatitis B vaccination are recommended, with the second dose administered at least one month after the first dose and the third dose available after six months. In special cases (e.g., travel, etc.), 3 doses can be completed on days 0, 7, and 21, with a 4th dose available 12 months after the initial vaccination. Regardless of the age group, there is no need to revaccinate if the vaccination schedule is interrupted. Also, hepatitis B vaccine should be transported and stored at 2-8°C to maintain a certain level of efficacy. A small number of people may experience mild adverse reactions to hepatitis B vaccination, such as local pain, muscle pain, and fever, mostly within 24 hours of injection, and mild vaccination reactions are more common in children than in adults. Do not be nervous when these occur, as symptoms will gradually decrease as the vaccine is metabolized. If symptoms continue to worsen, seek prompt medical attention.